Diuril Lyovac [As Sodium Salt]

Diuril Lyovac [As Sodium Salt] Brand names, Diuril Lyovac [As Sodium Salt] Analogs

Diuril Lyovac [As Sodium Salt] Brand Names Mixture

Supres 150 Tab (Chlorothiazide + Methyldopa)
Supres 250 Tab (Chlorothiazide + Methyldopa)

Diuril Lyovac [As Sodium Salt] Chemical_Formula

C₇H₆ClN₃O₄S₂

Diuril Lyovac [As Sodium Salt] RX_link

http://www.rxlist.com/cgi/generic2/chloroth.htm

Diuril Lyovac [As Sodium Salt] fda sheet

Diuril Lyovac [As Sodium Salt] msds (material safety sheet)

Diuril_Lyovac_[As_Sodium_Salt] MSDS

Diuril Lyovac [As Sodium Salt] Synthesis Reference

No information avaliable

Diuril Lyovac [As Sodium Salt] Molecular Weight

295.725 g/mol

Diuril Lyovac [As Sodium Salt] Melting Point

350 ^oC

Diuril Lyovac [As Sodium Salt] H₂O Solubility

266 mg/L

Diuril Lyovac [As Sodium Salt] State

Solid

Diuril Lyovac [As Sodium Salt] LogP

0.549

Diuril Lyovac [As Sodium Salt] Dosage Forms

Tablet (250, 500 mg)

Diuril Lyovac [As Sodium Salt] Indication

Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Diuril Lyovac [As Sodium Salt] Pharmacology

Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.

Diuril Lyovac [As Sodium Salt] Absorption